Affiliation:
1. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
2. UCLA Health System, Los Angeles, California, USA
Abstract
ABSTRACT
The performances of Vitek 2 AST-GN69 and AST-XN06 cards were compared to Clinical and Laboratory Standards Institute (CLSI) reference broth microdilution (BMD) for 99 isolates of
Pseudomonas aeruginosa
, 26
Acinetobacter baumannii
isolates, and 11
Stenotrophomonas maltophilia
isolates. In total, 15 antimicrobials were evaluated, with 11 for
P. aeruginosa
, 14 for
A. baumannii
, and 2 for
S. maltophilia
. Categorical agreement (CA) was assessed using both Vitek 2 breakpoints and 2016 CLSI M100S 26th edition breakpoints. The essential agreement values for
P. aeruginosa
,
A. baumannii
, and
S. maltophilia
were 99.5%, 99.2%, and 100%, respectively. The CA values for
P. aeruginosa
,
A. baumannii
, and
S. maltophilia
were 94.1%, 92.7%, and 95.5%, respectively, by the Vitek 2 breakpoints, and 93.4%, 92.3%, and 95.5%, respectively, by the CLSI breakpoints. Overall, the Vitek 2 performance was comparable to that of BMD using both Vitek 2 breakpoints and 2016 CLSI M100S 26th edition breakpoints. Improved performance was noted for the reformulated piperacillin-tazobactam and imipenem found on the AST-GN69 card, with no very major or major errors noted when using the CLSI breakpoints.
Publisher
American Society for Microbiology
Cited by
28 articles.
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