Histopathological Studies on Virulence of Dipeptidyl Aminopeptidase IV (DPPIV) of Porphyromonas gingivalis in a Mouse Abscess Model: Use of a DPPIV-Deficient Mutant-Reference-Cited by-同舟云学术

Histopathological Studies on Virulence of Dipeptidyl Aminopeptidase IV (DPPIV) of Porphyromonas gingivalis in a Mouse Abscess Model: Use of a DPPIV-Deficient Mutant

Published:2001-11 Issue:11 Volume:69 Page:7159-7161
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Yagishita Hisao¹,Kumagai Yumi²,Konishi Kiyoshi²,Takahashi Yukihiro²,Aoba Takaaki¹,Yoshikawa Masanosuke²

Affiliation:

1. Department of Pathology1 and

2. Department of Microbiology,2 Nippon Dental University, Fujimi 1-9-20, Chiyoda-ku, Tokyo 102-8159, Japan

Abstract

ABSTRACT To elucidate the role of dipeptidyl aminopeptidase IV (DPPIV) in the virulence of Porphyromonas gingivalis , mice were infected with either a wild-type strain or a DPPIV-deficient mutant using an abscess model. Histopathological analysis of the resulting lesions indicated that DPPIV participates in virulence through the destruction of connective tissue and the less effective mobilization of inflammatory cells.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.69.11.7159-7161.2001

Reference10 articles.

1. Oral infections;Allaker R. P.;Topley & Wilson's principles of bacteriology, virology and immunity,1998

2. Infections due to non-sporing anaerobic bacilli and cocci;Allen S. D.;Topley & Wilson's principles of bacteriology, virology and immunity,1998

3. The unique properties of dipeptidyl-peptidase IV (DPPIV/CD26) and the therapeutic potential of DPPIV inhibitors;Augustyns K.;Curr. Med. Chem.,1999

4. Pathogenic strategies of the oral anaerobe, Porphyromonas gingivalis;Cutler C. W.;Trends Microbiol.,1995

5. Virulence of a Porphyromonas gingivalis W83 mutant defective in the prtH gene

Cited by 31 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The first genomic characterization of a stable, hemin-dependent small colony variant strain of Staphylococcus epidermidis isolated from a prosthetic-joint infection;Frontiers in Microbiology;2023-10-19

2. Inherently and Conditionally Essential Protein Catabolism Genes of Porphyromonas gingivalis;Trends in Microbiology;2021-01

3. Enolase and dipeptidyl peptidase IV protein sub-unit vaccines are not protective against a lethal Streptococcus suis serotype 2 challenge in a mouse model of infection;BMC Veterinary Research;2019-12

4. The contribution ofTannerella forsythiadipeptidyl aminopeptidase IV in the breakdown of collagen;Molecular Oral Microbiology;2018-10-05

5. Antidiabetic “gliptins” affect biofilm formation by Streptococcus mutans;Microbiological Research;2018-04