Mycobacterium ulcerans Cytotoxicity in an Adipose Cell Model-Reference-Cited by-同舟云学术

Mycobacterium ulcerans Cytotoxicity in an Adipose Cell Model

Published:2001-11 Issue:11 Volume:69 Page:7182-7186
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Dobos Karen M.¹,Small Pamela L.²,Deslauriers Manon³,Quinn Fredrick D.³,King C. Harold¹

Affiliation:

1. Department of Medicine, Emory University School of Medicine, Emory University, Atlanta, Georgia 303031;

2. Department of Microbiology, University of Tennessee, Knoxville, Tennessee 379962; and

3. Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 303333

Abstract

ABSTRACT An adipose cell (SW872) model was developed to observe cellular necrosis and apoptosis upon Mycobacterium ulcerans infection and treatment with mycobacterial exudate. Apoptosis was likely due to secreted proteins, while necrosis was likely due to mycolactone. Our data suggest that additional factors in M . ulcerans may be involved in Buruli ulcer pathogenesis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.69.11.7182-7186.2001

Reference20 articles.

1. Serologic response to culture filtrate antigens of Mycobacterium ulcerans during Buruli ulcer disease;Dobos K. M.;Emerg. Infect. Dis.,2000

2. Necrosis of lung epithelial cells during infection with Mycobacterium tuberculosis is preceded by cell permeation;Dobos K. M.;Infect. Immun.,2000

3. Intracellular growth and cytotoxicity of Mycobacterium haemophilum in a human epithelial cell line (Hec-1-B)

4. Partial Purification and Characterization of Biological Effects of a Lipid Toxin Produced by Mycobacterium ulcerans

5. Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence;George K. M.;Science,1999

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