DNA Immunization with Trypanosoma cruzi HSP70 Fused to the KMP11 Protein Elicits a Cytotoxic and Humoral Immune Response against the Antigen and Leads to Protection-Reference-Cited by-同舟云学术

DNA Immunization with Trypanosoma cruzi HSP70 Fused to the KMP11 Protein Elicits a Cytotoxic and Humoral Immune Response against the Antigen and Leads to Protection

Published:2001-10 Issue:10 Volume:69 Page:6558-6563
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Planelles Lourdes¹,Thomas M. Carmen¹,Alonso Carlos²,López Manuel C.¹

Affiliation:

1. Departamento de Biologı́a Molecular, Instituto de Parasitologı́a y Biomedicina “López Neyra,” CSIC, 18001 Granada,1 and

2. Centro de Biologı́a Molecular “Severo Ochoa,” CSIC—UAM, 28049 Madrid,2 Spain

Abstract

ABSTRACT Murine immunization with Trypanosoma cruzi KMP11-HSP70 fused genes but not the KMP11 gene alone elicited both an immunoglobulin G2a long-lasting humoral immune response against KMP11 protein and activation of CD8 + cytotoxic T lymphocytes specific for two KMP11 peptides containing A2 motifs. Moreover, protection against the parasite challenge was observed after immunization with the chimeric gene.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.69.10.6558-6563.2001

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