DNA Adenine Methylase Is Essential for Viability and Plays a Role in the Pathogenesis of Yersinia pseudotuberculosis and Vibrio cholerae-Reference-Cited by-同舟云学术

DNA Adenine Methylase Is Essential for Viability and Plays a Role in the Pathogenesis of Yersinia pseudotuberculosis and Vibrio cholerae

Published:2001-12 Issue:12 Volume:69 Page:7610-7615
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Julio Steven M.¹,Heithoff Douglas M.¹,Provenzano Daniele²,Klose Karl E.²,Sinsheimer Robert L.¹,Low David A.¹,Mahan Michael J.¹

Affiliation:

1. Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California 93106,1 and

2. Department of Microbiology, University of Texas Health Science Center, San Antonio, Texas 78229-39002

Abstract

ABSTRACT Salmonella strains that lack or overproduce DNA adenine methylase (Dam) elicit a protective immune response to different Salmonella species. To generate vaccines against other bacterial pathogens, the dam genes of Yersinia pseudotuberculosis and Vibrio cholerae were disrupted but found to be essential for viability. Overproduction of Dam significantly attenuated the virulence of these two pathogens, leading to, in Yersinia , the ectopic secretion of virulence proteins ( Yersinia outer proteins) and a fully protective immune response in vaccinated hosts. Dysregulation of Dam activity may provide a means for the development of vaccines against varied bacterial pathogens.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.69.12.7610-7615.2001

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