Affiliation:
1. Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada
Abstract
The stringent response (SR) is a universal stress response that acts as a global regulator of bacterial physiology and virulence, and is a contributor to antibiotic tolerance and resistance. In most bacteria, the SR is controlled by a bifunctional enzyme, Rel, which both synthesizes and hydrolyzes the alarmone (p)ppGpp via two distinct catalytic domains.
Funder
European Society of Clinical Microbiology and Infectious Diseases
Gouvernement du Canada | Canadian Institutes of Health Research
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference51 articles.
1. Cashel M, Gentry DR, Hernandez VJ, Vinella D. 1996. The stringent response, p 1458–1496. In Neidhardt FC, Curtiss RI, Ingraham JL, Lin ECC, Low KB, Magasanik B, Reznikoff WS, Riley M, Schaechter M, Umbarger HE (ed), Escherichia coli and Salmonella: cellular and molecular biology. ASM Press, Washington, DC.
2. The stringent response and physiological roles of (pp)pGpp in bacteria
3. The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life
4. (p)ppGpp and the Stringent Response: An Emerging Threat to Antibiotic Therapy
5. Recent functional insights into the role of (p)ppGpp in bacterial physiology
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献