Therapeutic Drug Monitoring of Orally Administered Letermovir Prophylaxis in Allogeneic Hematopoietic Stem Cell Transplant Recipients

Author:

Royston Léna1ORCID,Masouridi-Levrat Stavroula2,Gotta Verena3,Royston Eva2,Pressacco-Brossier Caroline1,Abi Aad Yasmine1,Tonoli David4,Karmime Abderrahim4,Jayo Murielle4,Van Delden Christian1,Lescuyer Pierre4,Pfister Marc3,Chalandon Yves2,Neofytos Dionysios1ORCID

Affiliation:

1. Division of Infectious Diseases, University Hospital of Geneva, Geneva, Switzerland

2. Division of Hematology, Bone Marrow Transplant Unit, University Hospital of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland

3. Division of Pediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Basel, Switzerland

4. Division of Laboratory Medicine, University Hospital of Geneva, Geneva, Switzerland

Abstract

With balanced safety-efficacy profile, letermovir anti-cytomegalovirus (CMV) prophylaxis is used in hematopoietic stem cell transplant recipients (HSCTR). We assessed feasibility and usefulness of letermovir therapeutic drug monitoring (TDM) in HSCTR.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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