RNA Interference Mutant Induction In Vivo Demonstrates the Essential Nature of Trypanosome Flagellar Function during Mammalian Infection-Reference-Cited by-同舟云学术

RNA Interference Mutant Induction In Vivo Demonstrates the Essential Nature of Trypanosome Flagellar Function during Mammalian Infection

Published:2007-07 Issue:7 Volume:6 Page:1248-1250
ISSN:1535-9778
Container-title:Eukaryotic Cell
language:en
Short-container-title:Eukaryot Cell

Author:

Griffiths Samantha¹,Portman Neil¹,Taylor Philip R.¹,Gordon Siamon¹,Ginger Michael L.¹,Gull Keith¹

Affiliation:

1. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom

Abstract

ABSTRACT We demonstrate that trypanosomes compromised in flagellar function are rapidly cleared from infected mice. Analysis of the PFR2 bloodstream RNA interference mutant revealed that defective cell motility occurred prior to cytokinesis failure. This validation provides a paradigm for the flagellum as a target for future assays and interventions against this human pathogen.

Publisher

American Society for Microbiology

Subject

Molecular Biology,General Medicine,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/EC.00110-07

Reference20 articles.

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5. Broadhead, R., H. R. Dawe, H. Farr, S. Griffiths, S. R. Hart, N. Portman, M. K. Shaw, M. L. Ginger, S. J. Gaskell, P. G. McKean, and K. Gull. 2006. Flagellar motility is required for the viability of the bloodstream trypanosome. Nature440:224-227.

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