Human Papillomavirus 16 E5 Inhibits Interferon Signaling and Supports Episomal Viral Maintenance-Reference-Cited by-同舟云学术

Human Papillomavirus 16 E5 Inhibits Interferon Signaling and Supports Episomal Viral Maintenance

Published:2020-01-06 Issue:2 Volume:94 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Scott Matthew L.¹,Woodby Brittany L.¹,Ulicny Joseph²,Raikhy Gaurav¹,Orr A. Wayne³,Songock William K.⁴,Bodily Jason M.¹

Affiliation:

1. Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, and Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center—Shreveport, Shreveport, Louisiana, USA

2. School of Medicine, Louisiana State University Health Sciences Center—Shreveport, Shreveport Louisiana, USA

3. Department of Pathology and Translational Pathobiology, Center for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center—Shreveport, Shreveport, Louisiana, USA

4. Department of Biology, Centenary College of Louisiana, Shreveport, Louisiana, USA

Abstract

Persistent human papillomavirus infections can cause a variety of significant cancers. The ability of HPV to persist depends on evasion of the host immune system. In this study, we show that the HPV16 E5 protein can suppress an important aspect of the host immune response. In addition, we find that the E5 protein is important for helping the virus avoid integration into the host genome, which is a frequent step along the pathway to cancer development.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01582-19

Reference131 articles.

1. Chapter 1: HPV in the etiology of human cancer