AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19-Reference-Cited by-同舟云学术

AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Good Steven S.¹^ORCID,Westover Jonna²,Jung Kie Hoon²,Zhou Xiao-Jian¹,Moussa Adel¹,La Colla Paolo³,Collu Gabriella³,Canard Bruno⁴,Sommadossi Jean-Pierre¹

Affiliation:

1. Atea Pharmaceuticals, Inc., Boston, Massachusetts, USA

2. Department of Animal, Dairy & Veterinary Sciences, Utah State University, Logan, Utah, USA

3. Università degli Studi di Cagliari, Monserrato, Italy

4. Architecture et Fonction des Macromolécules Biologiques, Marseille, France

Abstract

The impact of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19, is global and unprecedented. Although remdesivir has recently been approved by the FDA to treat SARS-CoV-2 infection, no oral antiviral is available for outpatient treatment.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02479-20

Reference26 articles.

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