Cytocidal and Apoptotic Effects of the ClyA Protein from Escherichia coli on Primary and Cultured Monocytes and Macrophages-Reference-Cited by-同舟云学术

Cytocidal and Apoptotic Effects of the ClyA Protein from Escherichia coli on Primary and Cultured Monocytes and Macrophages

Published:2000-07 Issue:7 Volume:68 Page:4363-4367
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Lai Xin-He¹²,Arencibia Ignacio³,Johansson Anders⁴,Wai Sun Nyunt¹⁵,Oscarsson Jan¹,Kalfas Sotos⁴,Sundqvist Karl-Gösta³,Mizunoe Yoshimitsu⁵,Sjöstedt Anders²,Uhlin Bernt Eric¹

Affiliation:

1. Departments of Microbiology,1

2. Clinical Bacteriology,2

3. Clinical Immunology,3 and

4. Oral Biology,4 Umeå University, S-901 87 Umeå, Sweden, and

5. Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan5

Abstract

ABSTRACT Cytolysin A (ClyA) is a newly discovered cytolytic protein of Escherichia coli K-12 that mediates a hemolytic phenotype. We show here that highly purified ClyA and ClyA-expressing E. coli were cytotoxic and apoptogenic to fresh as well as cultured human and murine monocytes/macrophages.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.7.4363-4367.2000

Reference30 articles.

1. Kinase cascades regulating entry into apoptosis

2. Toxicity determined in vitro by morphological alterations and neutral red absorption;Borenfreud E.;Toxicol. Lett.,1985

3. Apoptosis induced by bacterial pathogens;Chen Y. J.;Microb. Pathog.,1994

4. Effects of cytochalasin and phalloidin on actin.

5. The Escherichia coli K-12 sheA gene encodes a 34-kDa secreted haemolysin;del Castillo I.;Mol. Microbiol.,1997

Cited by 76 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Reprogramming the tumor immune microenvironment using engineered dual-drug loaded Salmonella;Nature Communications;2024-08-06

2. Bacterial outer membrane vesicle nanorobot;Proceedings of the National Academy of Sciences;2024-07-15

3. A Review of the Use of Native and Engineered Probiotics for Colorectal Cancer Therapy;International Journal of Molecular Sciences;2024-03-31

4. Bacteria-Based Nanoprobes for Cancer Therapy;International Journal of Nanomedicine;2024-01

5. First Report and Characterization of the mcr-1 Positive Multidrug-Resistant Escherichia coli Strain Isolated from Pigs in Croatia;Microorganisms;2023-09-28