Analysis of Moloney murine leukemia virus revertants mutated at the gag-pol junction-Reference-Cited by-同舟云学术

Analysis of Moloney murine leukemia virus revertants mutated at the gag-pol junction

Published:1991-11 Issue:11 Volume:65 Page:6376-6379
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Odawara T¹,Yoshikura H¹,Ohshima M¹,Tanaka T¹,Jones D S¹,Nemoto F¹,Kuchino Y¹,Iwamoto A¹

Affiliation:

1. Department of Bacteriology, Faculty of Medicine, University of Tokyo, Japan.

Abstract

Among Moloney murine leukemia viruses (Mo-MuLVs) having stop codons other than UAG at the gag-pol junction, Mo-MuLV with UAA, but not with UGA, had a replication disadvantage. Mo-MuLV with a glutamine codon (CAG) at the junction did not replicate. A revertant of this virus consisted of the original virus and a virus with a deletion of the pol region. Protease and Pr65gag encoded by their respective genomes complemented each other.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.65.11.6376-6379.1991

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