Functional and Biochemical Characterization of the MazEF6 Toxin-Antitoxin System of Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Functional and Biochemical Characterization of the MazEF6 Toxin-Antitoxin System of Mycobacterium tuberculosis

Published:2022-04-19 Issue:4 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Chattopadhyay Gopinath¹,Bhasin Munmun¹,Ahmed Shahbaz¹,Gosain Tannu Priya²,Ganesan Srivarshini³,Das Sayan²,Thakur Chandrani⁴,Chandra Nagasuma⁴^ORCID,Singh Ramandeep²,Varadarajan Raghavan¹^ORCID

Affiliation:

1. Molecular Biophysics Unit, Indian Institute of Science, Bangalore, Karnataka, India

2. Tuberculosis Research Laboratory, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India

3. Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India

4. Department of Biochemistry, Indian Institute of Science, Bangalore, Karnataka, India

Abstract

M. tuberculosis harbors a large number of type II toxin-antitoxin (TA) systems, the exact roles for most of which are unclear. Prior studies have reported that overexpression of several of these type II toxins inhibits bacterial growth and contributes to the formation of drug-tolerant populations in vitro .

Funder

Council of Scientific and Industrial Research, India

Department of Biotechnology, Ministry of Science and Technology, India

Department of Biotechnology, Ministry of Science and Technology, India (DBT), DBT-Wellcome India Alliance

Department of Science and Technology, Ministry of Science and Technology, India

Ministry of Education, India

University Grants Commission

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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