Fusions of the lac and trp Regions of the Escherichia coli Chromosome-Reference-Cited by-同舟云学术

Fusions of the lac and trp Regions of the Escherichia coli Chromosome

Published:1970-12 Issue:3 Volume:104 Page:1273-1279
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Miller Jeffrey H.¹²³,Reznikoff William S.¹²³,Silverstone Allan E.¹²³,Ippen Karin¹²³,Signer Ethan R.¹²³,Beckwith Jonathan R.¹²³

Affiliation:

1. Department of Bacteriology and Immunology, Harvard Medical School, Boston, Massachusetts 02115

2. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

3. Service de Génétique Microbienne, Institut Pasteur, Paris, France

Abstract

Two classes of strains were studied in which the lac operon is transposed to a chromosomal site close to the tonB and trp loci. The two classes differ in the orientation of the lac region on the chromosome. In both types of strains, tonB mutants were selected in which deletions removing the tonB locus also caused a fusion of the lac and trp regions. The study of the properties of such fusion strains provides information on the control of both the lac and trp operons.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.104.3.1273-1279.1970

Reference32 articles.

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5. Biochemical evidence that the operator locus is distinct from the z gene in the lac operon of E. coli;Bhorjee J. S.;J. Mol. Biol.,1969

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