Role of the Staphylococcus aureus Extracellular Loop of GraS in Resistance to Distinct Human Defense Peptides in PMN and Invasive Cardiovascular infections-Reference-Cited by-同舟云学术

Role of the Staphylococcus aureus Extracellular Loop of GraS in Resistance to Distinct Human Defense Peptides in PMN and Invasive Cardiovascular infections

Published:2021-09-16 Issue:10 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Cheung Ambrose L.¹,Cho Junho¹,Bayer Arnold S.²³⁴,Yeaman Michael R.²³⁴⁵^ORCID,Xiong Yan Q.²³⁴,Donegan Niles P.¹^ORCID,Mikheyeva Irina V.¹,Lee Gi Yong⁶,Yang Soo-Jin⁶^ORCID

Affiliation:

1. Department of Microbiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA

2. The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA

3. Department of Medicine, Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, California, USA

4. The David Geffen School of Medicine at UCLA, Los Angeles, California, USA

5. Department of Medicine, Division of Molecular Medicine, Harbor-UCLA Medical Center, Torrance, California, USA

6. Department of Veterinary Microbiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea

Abstract

GraS is a membrane sensor in Staphylococcus aureus that induces mprF and dltABCD expression to alter the surface positive charge upon exposure to cationic human defense peptides (HDPs). The sensing domain of GraS likely resides in the 9-residue extracellular loop (EL).

Funder

CF Research Foundation

Dartmouth | Audrey and Theodor Geisel School of Medicine at Dartmouth

HHS | National Institutes of Health

National Research Foundation of Korea

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00347-21

Reference41 articles.