Activity of CcpA-Regulated GH18 Family Glycosyl Hydrolases That Contributes to Nutrient Acquisition and Fitness in Enterococcus faecalis

Author:

Keffeler Erica C.1,Iyer Vijayalakshmi S.2,Henderson Andrew J.2,Huck Ian L.2,Schwarting Nancy1,Cortez Analaura1,Hancock Lynn E.1ORCID

Affiliation:

1. Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA

2. Division of Biology, Kansas State University, Manhattan, Kansas, USA

Abstract

Enterococcus faecalis has emerged as a multidrug-resistant (MDR) nosocomial pathogen that causes life-threatening health care-associated infections. Nutrient acquisition systems and immune evasion strategies are key factors that contribute to enterococcal colonization and influence the overall pathogenic potential of this organism.

Funder

NIGMS

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference79 articles.

1. Lebreton F, Willems RJL, Gilmore MS. 2014. Enterococcus diversity, origins in nature, and gut colonization. In Gilmore MS, Clewell DB, Ike Y, Shankar N (ed), Enterococci: from commensals to leading causes of drug resistant infection. Massachusetts Eye Infirmary, Boston, MA. https://www.ncbi.nlm.nih.gov/books/NBK190427/.

2. The Enterococcus: a Model of Adaptability to Its Environment

3. Antimicrobial-resistant pathogens associated with adult healthcare-associated infections: Summary of data reported to the National Healthcare Safety Network, 2015–2017

4. Pathogenicity of Enterococci

5. Carbon catabolite repression in bacteria: many ways to make the most out of nutrients

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