Genetic Basis for Natural and Acquired Resistance to the Diarylquinoline R207910 in Mycobacteria-Reference-Cited by-同舟云学术

Genetic Basis for Natural and Acquired Resistance to the Diarylquinoline R207910 in Mycobacteria

Published:2006-08 Issue:8 Volume:50 Page:2853-2856
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Petrella Stephanie¹,Cambau Emmanuelle¹,Chauffour Aurelie¹,Andries Koen²,Jarlier Vincent¹,Sougakoff Wladimir¹

Affiliation:

1. Laboratoire de Recherche Moléculaire sur les Antibiotiques, LRMA INSERM U655, Université Pierre et Marie Curie, AP-HP CHU Pitié-Salpêtrière, Paris, France

2. Johnson and Johnson Pharmaceutical Research and Development, Janssen Pharmaceutica N.V., Beerse, Belgium

Abstract

ABSTRACT The atpE gene encoding the subunit c of the ATP synthase of Mycobacterium tuberculosis , the target of the new diarylquinoline drug R207910, has been sequenced from in vitro mutants resistant to the drug. The previously reported mutation A63P and a new mutation, I66M, were found. The genetic diversity of atpE in 13 mycobacterial species was also investigated, revealing that the region involved in resistance to R207910 is conserved, except in Mycobacterium xenopi in which the highly conserved residue Ala63 is replaced by Met, a modification that may be associated with the natural resistance of M. xenopi to R207910.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00244-06

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