Tauroursodeoxycholic Acid Inhibits Clostridioides difficile Toxin-Induced Apoptosis-Reference-Cited by-同舟云学术

Tauroursodeoxycholic Acid Inhibits Clostridioides difficile Toxin-Induced Apoptosis

Published:2022-08-18 Issue:8 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Pike Colleen M.¹,Tam John²,Melnyk Roman A.²³⁴^ORCID,Theriot Casey M.¹^ORCID

Affiliation:

1. Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA

2. Molecular Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada

3. Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

4. SickKids Proteomics Analytics Robotics Chemical Biology Drug Discovery Facility, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada

Abstract

C. difficile infection (CDI) is a highly inflammatory disease mediated by the production of two large toxins that weaken the intestinal epithelium and cause extensive colonic tissue damage. Antibiotic alternative therapies for CDI are urgently needed as current antibiotic regimens prolong the perturbation of the microbiota and lead to high disease recurrence rates.

Funder

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00153-22

Reference62 articles.

1. Trends in U.S. Burden of Clostridioides difficile Infection and Outcomes

2. Clostridium difficile Toxin Biology

3. Clostridium difficile infection