Subacute Toxicity of Colistin Methanesulfonate in Rats: Comparison of Various Intravenous Dosage Regimens-Reference-Cited by-同舟云学术

Subacute Toxicity of Colistin Methanesulfonate in Rats: Comparison of Various Intravenous Dosage Regimens

Published:2008-03 Issue:3 Volume:52 Page:1159-1161
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wallace Stephanie J.¹,Li Jian¹,Nation Roger L.¹,Rayner Craig R.¹,Taylor David²,Middleton Deborah³,Milne Robert W.⁴,Coulthard Kingsley⁴⁵,Turnidge John D.⁶

Affiliation:

1. Facility for Anti-infective Drug Development and Innovation

2. Department of Pharmaceutical Biology, Victorian College of Pharmacy, Monash University, Parkville, Melbourne, Victoria 3052

3. CSIRO Australian Animal Health Laboratory, East Geelong, Victoria 3220

4. Sansom Institute, School of Pharmacy and Medical Science, University of South Australia, Adelaide, South Australia 5000

5. Department of Pharmacy

6. Division of Laboratory Medicine, Women's and Children's Hospital, North Adelaide, South Australia 5006, Australia

Abstract

ABSTRACT The relative nephro- and neurotoxicity of colistin methanesulfonate (CMS) was investigated with rats during 7 days of intravenous administration in regimens mimicking twice- and once-daily dosing of a clinically relevant dose for humans. Histological examination revealed more-severe renal lesions with the regimen corresponding to once-daily dosing, indicating that the potential for renal toxicity may be greater with extended-interval dosing.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01101-07

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