<i>ERG11</i> Analysis among Clinical Isolates of Trichosporon asahii with Different Azole Susceptibility Profiles-Reference-Cited by-同舟云学术

ERG11 Analysis among Clinical Isolates of Trichosporon asahii with Different Azole Susceptibility Profiles

Published:2022-12-20 Issue:12 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Nobrega de Almeida João¹²³^ORCID,Jimenez-Ortigosa Cristina¹^ORCID,Francisco Elaine Cristina²^ORCID,Colombo Arnaldo L.²^ORCID,Perlin David S.¹^ORCID

Affiliation:

1. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA

2. Special Mycology Laboratory, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil

3. Microbiology Laboratory, Hospital Israelita Albert Einstein, São Paulo, Brazil

Abstract

We analyzed a cohort of Trichosporon asahii strains with different MICs of fluconazole and voriconazole and evaluated the presence of ERG11 mutations. ERG11 mutation conferring an amino acid change was found and its resistance potential was evaluated by cloning into Saccharomyces cerevisiae susceptible host strain. Transformants were not resistant to either fluconazole nor voriconazole.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01101-22

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