Author:
Rotem Shahar,Bar-Haim Erez,Cohen Hila,Elia Uri,Ber Raphael,Shafferman Avigdor,Cohen Ofer
Abstract
ABSTRACTThis study examines the efficacy, bacterial load, and humoral response of extensively delayed ciprofloxacin or doxycycline treatments following airway exposure of mice toFrancisella tularensissubsp.holarctica(strain LVS) or to the highly virulentF. tularensissubsp.tularensis(strain SchuS4). A delay in onset of both antibiotic treatments allowed the rescue of all LVS-infected animals. However, for animals infected with SchuS4, only ciprofloxacin was efficacious and prolongation of treatment rescued all animals.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
15 articles.
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