Association between Vancomycin Pharmacokinetic Parameters and Clinical and Microbiological Efficacy in a Cohort of Neonatal Patients-Reference-Cited by-同舟云学术

Association between Vancomycin Pharmacokinetic Parameters and Clinical and Microbiological Efficacy in a Cohort of Neonatal Patients

Published:2022-11-15 Issue:11 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Mejías-Trueba Marta¹²,Alonso-Moreno Marta¹,Gutiérrez-Valencia Alicia²^ORCID,Herrera-Hidalgo Laura¹²^ORCID,Guisado-Gil Ana Belén¹²³^ORCID,Jiménez-Parrilla Francisco⁴,Varela-Rubio Elena⁴,Gil-Navarro Maria Victoria¹³

Affiliation:

1. Department of Pharmacy, University Hospital Virgen del Rocio, Seville, Spain

2. Department of Infectious Diseases, Microbiology and Preventive Medicine, Infectious Diseases Research Group, Institute of Biomedicine of Seville (IBiS), University of Seville/Spanish National Research Council/University Hospital Virgen del Rocio, Seville, Spain

3. Centre for Biomedical Research Network (CIBER) on Infectious Diseases, Madrid, Spain

4. Department of Neonatology, Hospital Universitario Virgen del Rocío, Seville, Spain

Abstract

Vancomycin pharmacokinetic/pharmacodynamic (PK/PD) targets have not been validated in the neonatal population as no specifically designed studies are available. The main goal of this study was to analyze the therapeutic vancomycin regimen, the 24-h area under the curve (AUC 24 ), and the trough plasma concentration ( C t ) obtained that achieved clinical and microbiological effectiveness in a cohort of neonates.

Funder

MEC | Instituto de Salud Carlos III

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01109-22

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