Author:
Baraka Vito,Tinto Halidou,Valea Innocent,Fitzhenry Robert,Delgado-Ratto Christopher,Mbonye Martin K.,Van Overmeir Chantal,Rosanas-Urgell Anna,Van geertruyden Jean-Pierre,D'Alessandro Umberto,Erhart Annette
Abstract
ABSTRACTPlasmodium falciparumPfcrt-76 andPfmdr1-86 gene polymorphisms were determined during a clinical trial in Burkina Faso comparing the efficacies of dihydroartemisinin-piperaquine (DHA-PPQ) and artemether-lumefantrine (AL). Significant selection ofPfcrt-K76 was observed after exposure to AL and DHA-PPQ, as well as selection ofPfmdr1-N86 after AL but not DHA-PPQ treatment, suggesting reverse selection on thePfcrtgene by PPQ. These results support the rational use of DHA-PPQ in settings where chloroquine (CQ) resistance is high.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
37 articles.
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