Cryptopleurine Resistance: Genetic Locus for a 40 S Ribosomal Component in Saccharomyces cerevisiae-Reference-Cited by-同舟云学术

Cryptopleurine Resistance: Genetic Locus for a 40 S Ribosomal Component in Saccharomyces cerevisiae

Published:1974-12 Issue:3 Volume:120 Page:1308-1314
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Grant Paul¹,Sánchez Lucas¹,Jiménez Antonio¹

Affiliation:

1. Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706, and Instituto de Biologia Celular, Velazquez 144, Madrid 6, Spain

Abstract

Mutants resistant to the phenanthrene alkaloids tylophorine, tylocrebrine, and cryptopleurine have been isolated from the yeast Saccharomyces cerevisiae . A single recessive nuclear gene was responsible for resistance. This resistance locus, cry , was closely linked to the mating locus (2.2 centimorgans). The resistance was ribosomal and was due to an altered 40 S ribosomal subunit. The mode of action of these drugs has been examined, and they appear to inhibit the translocation phase of protein synthesis.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.120.3.1308-1314.1974

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