Activities of Dalbavancin against a Worldwide Collection of 81,673 Gram-Positive Bacterial Isolates

Abstract

ABSTRACT Dalbavancin, a long-acting lipoglycopeptide, was evaluated against 81,673 isolates of staphylococci, enterococci, and streptococci collected from 33 countries during worldwide resistance surveillance (2002 to 2007). Regardless of susceptibility to oxacillin, comparable potencies for dalbavancin against Staphylococcus aureus and coagulase-negative staphylococci from all countries were noted (MIC 90 , 0.06 to 0.12 μg/ml). Vancomycin-susceptible Enterococcus spp. had dalbavancin MIC 90 s comparable to those for staphylococci, whereas vancomycin-resistant strains were more resistant (MIC 50 , >4 μg/ml). β-Hemolytic and viridians group streptococci were very susceptible to dalbavancin (MIC 90 , ≤0.03 μg/ml). Overall, dalbavancin was ≥16-fold more active than vancomycin against the monitored gram-positive species.