In Vitro Study of the Synergistic Effect of an Enzyme Cocktail and Antibiotics against Biofilms in a Prosthetic Joint Infection Model-Reference-Cited by-同舟云学术

In Vitro Study of the Synergistic Effect of an Enzyme Cocktail and Antibiotics against Biofilms in a Prosthetic Joint Infection Model

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Poilvache Hervé¹²³^ORCID,Ruiz-Sorribas Albert²,Cornu Olivier¹³,Van Bambeke Françoise²^ORCID

Affiliation:

1. Université catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Neuromusculoskeletal Laboratory, Brussels, Belgium

2. Université catholique de Louvain, Louvain Drug Research Institute, Pharmacologie cellulaire et moléculaire, Brussels, Belgium

3. Cliniques Universitaires Saint-Luc, Orthopedic Surgery Department, Brussels, Belgium

Abstract

Prosthetic joint infections (PJI) are frequent complications of arthroplasties. Their treatment is made complex by the rapid formation of bacterial biofilms, limiting the effectiveness of antibiotic therapy.

Funder

Fonds De La Recherche Scientifique - FNRS

FNRS | Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture

Service Public de Wallonie

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01699-20

Reference55 articles.

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2. Comparative Epidemiology of Revision Arthroplasty: Failed THA Poses Greater Clinical and Economic Burdens Than Failed TKA

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4. Implant infections: adhesion, biofilm formation and immune evasion

5. Antimicrobial Tolerance in Biofilms

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