Updates to Clostridium difficile Spore Germination-Reference-Cited by-同舟云学术

Updates to Clostridium difficile Spore Germination

Published:2018-08-15 Issue:16 Volume:200 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Kochan Travis J.¹,Foley Matthew H.¹,Shoshiev Michelle S.¹,Somers Madeline J.¹,Carlson Paul E.²,Hanna Philip C.¹

Affiliation:

1. University of Michigan, Department of Microbiology and Immunology, Ann Arbor, Michigan, USA

2. U.S. Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, Maryland, USA

Abstract

Germination of Clostridium difficile spores is a crucial early requirement for colonization of the gastrointestinal tract. Likewise, C. difficile cannot cause disease pathologies unless its spores germinate into metabolically active, toxin-producing cells.

Funder

University of Michigan Medical School Endowment for the Basic Sciences

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00218-18

Reference100 articles.

1. Burden ofClostridium difficileInfection in the United States

2. Diversity of Clostridium difficile PCR ribotypes in Europe: results from the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID), 2012 and 2013