R5 Strains of Human Immunodeficiency Virus Type 1 from Rapid Progressors Lacking X4 Strains Do Not Possess X4-Type Pathogenicity in Human Thymus-Reference-Cited by-同舟云学术

R5 Strains of Human Immunodeficiency Virus Type 1 from Rapid Progressors Lacking X4 Strains Do Not Possess X4-Type Pathogenicity in Human Thymus

Published:1999-09 Issue:9 Volume:73 Page:7817-7822
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Berkowitz Robert D.¹,van ’t Wout Angélique B.²,Kootstra Neeltje A.²,Moreno Mary E.¹,Linquist-Stepps Valerie D.¹,Bare Christopher¹,Stoddart Cheryl A.¹,Schuitemaker Hanneke²,McCune Joseph M.¹³

Affiliation:

1. Gladstone Institute of Virology and Immunology1 and

2. Department of Clinical Viro-Immunology, Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands2

3. Departments of Microbiology and Immunology and Medicine,3University of California at San Francisco, San Francisco, California, and

Abstract

ABSTRACT Some individuals infected with only R5 strains of human immunodeficiency virus type 1 progress to AIDS as quickly as individuals harboring X4 strains. We determined that three R5 viruses were much less pathogenic than an X4 virus in SCID-hu Thy/Liv mice, suggesting that R5 virus-mediated rapid disease progression is associated with host, not viral, factors.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.73.9.7817-7822.1999

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