Human Papillomavirus Type 16 E7 DNA Vaccine: Mutation in the Open Reading Frame of E7 Enhances Specific Cytotoxic T-Lymphocyte Induction and Antitumor Activity-Reference-Cited by-同舟云学术

Human Papillomavirus Type 16 E7 DNA Vaccine: Mutation in the Open Reading Frame of E7 Enhances Specific Cytotoxic T-Lymphocyte Induction and Antitumor Activity

Published:1999-09 Issue:9 Volume:73 Page:7877-7881
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Shi Wei¹,Bu Ping¹,Liu Jianzhong¹,Polack Axel²,Fisher Susan³,Qiao Liang¹

Affiliation:

1. Department of Microbiology and Immunology1 and

2. National Research Center for Environment and Health, Institute of Clinical Molecular Biology and Tumor Genetics, D-81377 Munich, Germany2

3. Cardinal Bernardin Cancer Center,3 Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153, and

Abstract

ABSTRACT A human papillomavirus type 16 E7 DNA vaccine with the open reading frame encoding mutations in two zinc-binding motifs expressed a rapidly degraded E7 protein. This vaccine induced a significantly stronger E7-specific cytotoxic T-lymphocyte response and better tumor protection in mice than did a wild-type E7 DNA vaccine expressing a stable E7 protein.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.73.9.7877-7881.1999

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