Whole-Genome Analysis of Clinical Vibrio cholerae O1 in Kolkata, India, and Dhaka, Bangladesh, Reveals Two Lineages of Circulating Strains, Indicating Variation in Genomic Attributes

Author:

Morita Daichi1,Morita Masatomo2,Alam Munirul3,Mukhopadhyay Asish K.4,Johura Fatema-tuz3,Sultana Marzia3,Monira Shirajum3,Ahmed Niyaz35,Chowdhury Goutam4,Dutta Shanta4,Ramamurthy Thandavarayan4,Samanta Prosenjit4,Takahashi Eizo1,Okamoto Keinosuke1,Izumiya Hidemasa2ORCID,Ohnishi Makoto2

Affiliation:

1. Collaborative Research Center of Okayama University for Infectious Diseases in India, Kolkata, India

2. Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan

3. icddr,b - International Center for Diarrheal Diseases Research, Bangladesh, Dhaka, Bangladesh

4. ICMR—National Institute of Cholera and Enteric Diseases, Kolkata, India

5. Department of Biotechnology and Bioinformatics, University of Hyderabad, Hyderabad, India

Abstract

Cholera continues to be a global concern, as large epidemics have occurred recently in Haiti, Yemen, and countries of sub-Saharan Africa. A single lineage of Vibrio cholerae O1 has been considered to be introduced into these regions from South Asia and to cause the spread of cholera. Using genomic epidemiology, we showed that two distinct lineages exist in Bengal, one of which is linked to the global lineage. The other lineage was found only in Iran, Iraq, and countries in Asia and differed from the global lineage regarding cholera toxin variant and drug resistance profile. Therefore, the potential transmission of this lineage to other regions would likely cause worldwide cholera spread and may result in this lineage replacing the current global lineage.

Funder

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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