Evolution of the Gut Microbiome in HIV-Exposed Uninfected and Unexposed Infants during the First Year of Life

Author:

Jackson Conner L.1,Frank Daniel N.2,Robertson Charles E.2,Ir Diana2,Kofonow Jennifer M.2,Montlha Mahlodi P.3,Mutsaerts Eleonora A. M. L.3,Nunes Marta C.3,Madhi Shabir A.34,Ghosh Debashis1,Weinberg Adriana256ORCID

Affiliation:

1. Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

2. Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

3. South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit and Department of Science and Technology/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

4. African Leadership in Vaccinology Expertise, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

5. Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

6. Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

Abstract

HIV-exposed uninfected infants (HEU) are highly vulnerable to infections in the first 6 months of life, and this vulnerability decreases to the age of 24 months. Because the microbiome plays a critical role in the education of the infant immune system, which protects them against infections, we characterized the gut microbiomes of HEU and HIV-unexposed infants (HUU) in the first year of life.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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