Phosphatidylinositol 3-Kinase (PI3K) Orchestrates Aspergillus fumigatus-Induced Eosinophil Activation Independently of Canonical Toll-Like Receptor (TLR)/C-Type-Lectin Receptor (CLR) Signaling-Reference-Cited by-同舟云学术

Phosphatidylinositol 3-Kinase (PI3K) Orchestrates Aspergillus fumigatus-Induced Eosinophil Activation Independently of Canonical Toll-Like Receptor (TLR)/C-Type-Lectin Receptor (CLR) Signaling

Published:2022-08-30 Issue:4 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Dietschmann Axel¹,Schruefer Sebastian²,Westermann Stefanie¹,Henkel Fiona³,Castiglione Kirstin¹,Willebrand Ralf¹,Adam Jasmin²,Ruland Jürgen⁴,Lang Roland²^ORCID,Sheppard Donald C.⁵⁶,Esser-von-Bieren Julia³,Radtke Daniel¹,Krappmann Sven²,Voehringer David¹^ORCID

Affiliation:

1. Department of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU), Erlangen, Germany

2. Institute of Clinical Microbiology, Immunology, and Hygiene, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU), Erlangen, Germany

3. Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, 80802 Munich, Germany

4. Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, Munich, Germany

5. Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada

6. Department of Medicine, Infectious Diseases, and Immunity in Global Health Program, Centre for Translational Biology, McGill University Health Centre, Montreal, Quebec, Canada

Abstract

Allergic bronchopulmonary aspergillosis (ABPA) is caused by the fungusAspergillus fumigatus, afflicts about five million patients globally, and is still a noncurable disease. ABPA is associated with pronounced lung eosinophilia.

Funder

Deutsche Forschungsgemeinschaft

Medical Faculty FAU Erlangen-Nuremberg

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01239-22

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