VEGF-Mediated Augmentation of Autophagic and Lysosomal Activity in Endothelial Cells Defends against Intracellular Streptococcus pyogenes

Author:

Lu Shiou-Ling1,Omori Hiroko2,Zhou Yi1,Lin Yee-Shin34,Liu Ching-Chuan45,Wu Jiunn-Jong6,Noda Takeshi17ORCID

Affiliation:

1. Center for Frontier Oral Science, Graduate School of Dentistry, Osaka University, Osaka, Japan

2. Research Institute for Microbial Disease, Osaka University, Osaka, Japan

3. Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan

4. Center of Infectious Disease and Signaling Research, College of Medicine, National Cheng Kung University, Tainan, Taiwan

5. Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan

6. Department of Biotechnology and Laboratory Science in Medicine, College of Biomedical Science and Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan

7. Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan

Abstract

Sepsis caused by Streptococcus pyogenes is a life-threatening condition. Blood vessel endothelial cells should serve as a barrier to infection, although we recently reported that endothelial cells allow intracellular GAS proliferation due to defective xenophagy.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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