Impact of the Inclusion of an Aminoglycoside to the Initial Empirical Antibiotic Therapy for Gram-Negative Bloodstream Infections in Hematological Neutropenic Patients: a Propensity-Matched Cohort Study (AMINOLACTAM Study)-Reference-Cited by-同舟云学术

Impact of the Inclusion of an Aminoglycoside to the Initial Empirical Antibiotic Therapy for Gram-Negative Bloodstream Infections in Hematological Neutropenic Patients: a Propensity-Matched Cohort Study (AMINOLACTAM Study)

Published:2021-07-16 Issue:8 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Albasanz-Puig A.¹²³^ORCID,Gudiol C.¹²³⁴⁵^ORCID,Puerta-Alcalde P.³⁶,Ayaz C. M.⁷,Machado M.⁸,Herrera F.⁹,Martín-Dávila P.¹⁰,Laporte-Amargós J.¹²³,Cardozo C.⁶,Akova M.⁷,Álvarez-Uría A.⁸,Torres D.⁹,Fortún J.¹⁰,García-Vidal C.³⁶,Muñoz P.⁸^ORCID,Bergas A.¹,Pomares H.¹¹,Mercadal S.¹¹,Durà-Miralles X.¹²³,García-Lerma E.¹²,Pallarès N.¹²,Carratalà J.¹²³⁴

Affiliation:

1. Infectious Disease Department, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain

2. Infections of the Respiratory Tract and in Immunocompromised Patients Research Group, Infectious Diseases and Transplantation Program, Institut d’Investigació Biomèdica de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain

3. Spanish Network for Research in Infectious Disease, Instituto de Salud Carlos III, Madrid, Spain

4. University of Barcelona, Barcelona, Spain

5. Institut Català d’Oncologia, L’Hospitalet de Llobregat, Barcelona, Spain

6. Infectious Diseases Department, Hospital Clínic i Provincial, Barcelona, Spain

7. Hacettepe University School of Medicine, Ankara, Turkey

8. Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain

9. Infectious Diseases Section, Department of Medicine, Centro de Educación Médica e Investigaciones Clínicas, Buenos Aires, Argentina

10. Infectious Diseases Department, Ramón y Cajal Hospital, Madrid, Spain

11. Hematology Department, Institut Català d’Oncologia, L’Hospitalet de Llobregat, Barcelona, Spain

12. Biostatistics Unit, Institut d’Investigació Biomèdica de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain

Abstract

To test the hypothesis that the addition of an aminoglycoside to a β-lactam antibiotic could provide better outcomes than β-lactam monotherapy for the initial empirical treatment of hematological neutropenic patients with subsequently documented Gram-negative bacillus (GNB) bloodstream infection (BSI), a multinational, retrospective, cohort study of GNB BSI episodes in hematological neutropenic patients in six centers (2010 to 2017) was conducted. Combination therapy (β-lactam plus aminoglycoside) was compared to β-lactam monotherapy.

Funder

MEC | Instituto de Salud Carlos III

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00045-21

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