Antiserum to scrapie-associated fibril protein cross-reacts with Spiroplasma mirum fibril proteins

Author:

Bastian F O1,Jennings R A1,Gardner W A1

Affiliation:

1. Department of Pathology, College of Medicine, University of South Alabama, Mobile 36617.

Abstract

Protease-resistant fibril proteins purified from Spiroplasma mirum and from Creutzfeldt-Jakob disease-infected brain tissues reacted with antisera to scrapie-associated fibrils on Western immunoblot analysis. These data suggest that there are conformational similarities among spiroplasma proteins and infection-specific proteins of the transmissible spongiform encephalopathies.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference24 articles.

1. Spiroplasma-like inclusions in Creutzfeldt-Jakob disease;Bastian F. O.;Arch. Pathol. Lab. Med.,1979

2. Neuropathology of spiroplasma infection in the rat brain;Bastian F. O.;Am. J. Pathol.,1984

3. Spiroplasma-associated fibrils;Bastian F. O.;J. Neuropathol. Exp. Neurol.,1984

4. Highly selective extraction of spiralin from the Spiroplasma citri cell membrane with alkyl-N-sulfobetaines;Blanchard A.;Biochimie,1985

5. Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain;Chesebro B.;Nature (London),1985

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