Cutibacterium acnes Central Nervous System Catheter Infection Induces Long-Term Changes in the Cerebrospinal Fluid Proteome

Author:

Beaver Matthew1,Lagundzin Dragana2,Thapa Ishwor3,Lee Junghyae4,Ali Hesham3,Kielian Tammy5ORCID,Skar Gwenn L.1ORCID

Affiliation:

1. Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska, USA

2. Mass Spectrometry and Proteomics Core Facility, University of Nebraska Medical Center, Omaha, Nebraska, USA

3. College of Information Science and Technology, University of Nebraska Omaha, Omaha, Nebraska, USA

4. Department of Biostatistics, University of Nebraska Medical Center, Omaha, Nebraska, USA

5. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA

Abstract

Cutibacterium acnes is the third most common cause of cerebrospinal fluid (CSF) shunt infection and is likely underdiagnosed due to the difficulty in culturing this pathogen. Shunt infections lead to grave neurologic morbidity for patients especially when there is a delay in diagnosis.

Funder

Legeschulte & Wiese Fund at the University of Nebraska Medical Center

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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