Effects of Low-Level Persistent Infection on Maintenance of Immunity by CD4 T Cell Subsets and Th1 Cytokines

Author:

Ibitokou Samad A.1ORCID,Gbedande Komi1ORCID,Opata Michael M.1,Carpio Victor H.2,Marshall Karis M.1,Stephens Robin12ORCID

Affiliation:

1. Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA

2. Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA

Abstract

CD4 T cells are required, along with antibodies, for complete protection from blood-stage infection with Plasmodium spp., which cause malaria. Without continuous exposure, as on emigration of people from endemic areas, protection from malaria decays.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference46 articles.

1. WHO. 2020. World malaria report 2020: 20 years of global progress and challenges. World Health Organization, Geneva, Switzerland.

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3. Plasmodium malariaeBlood-Stage Dynamics

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5. Longevity of the Immune Response and Memory to Blood-Stage Malaria Infection

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