<i>In Vitro</i> Selection Identifies Staphylococcus aureus Genes Influencing Biofilm Formation-Reference-Cited by-同舟云学术

In Vitro Selection Identifies Staphylococcus aureus Genes Influencing Biofilm Formation

Published:2023-03-15 Issue:3 Volume:91 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Long Dustin R.¹,Penewit Kelsi²,Lo Hsin-Yu²,Almazan Jared²,Holmes Elizabeth A.²,Bryan Andrew B.²,Wolter Daniel J.³,Lewis Janessa D.²,Waalkes Adam²,Salipante Stephen J.²^ORCID

Affiliation:

1. Division of Critical Care Medicine, Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, Washington, USA

2. Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA

3. Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA

Abstract

Staphylococcus aureus generates biofilms during many chronic human infections, which contributes to its growth and persistence in the host. Multiple genes and pathways necessary for S. aureus biofilm production have been identified, but knowledge is incomplete, and little is known about spontaneous mutations that increase biofilm formation as infection progresses.

Funder

Vertex Pharmaceuticals

Cystic Fibrosis Foundation

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00538-22

Reference61 articles.