The Impacts of msaABCR on sarA -Associated Phenotypes Are Different in Divergent Clinical Isolates of Staphylococcus aureus-Reference-Cited by-同舟云学术

The Impacts of msaABCR on sarA -Associated Phenotypes Are Different in Divergent Clinical Isolates of Staphylococcus aureus

Published:2020-01-22 Issue:2 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Rom Joseph S.¹,Ramirez Aura M.¹,Beenken Karen E.¹,Sahukhal Gyan S.²,Elasri Mohamed O.²,Smeltzer Mark S.¹³

Affiliation:

1. Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

2. Center for Molecular and Cellular Biosciences, University of Southern Mississippi, Hattiesburg, Mississippi, USA

3. Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Abstract

The staphylococcal accessory regulator ( sarA ) plays an important role in Staphylococcus aureus infections, including osteomyelitis, and the msaABCR operon has been implicated as an important factor in modulating expression of sarA . Thus, we investigated the contribution of msaABCR to sarA -associated phenotypes in the S. aureus clinical isolates LAC and UAMS-1. Mutation of msaABCR resulted in reduced production of SarA and a reduced capacity to form a biofilm in both strains.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Center for Research Resources

HHS | NIH | National Institute of General Medical Sciences

DOD | United States Army | MEDCOM | Congressionally Directed Medical Research Programs

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00530-19

Reference53 articles.