Role of Supramolecule ErpY-Like Lipoprotein of Leptospira in Thrombin-Catalyzed Fibrin Clot Inhibition and Binding to Complement Factors H and I, and Its Diagnostic Potential-Reference-Cited by-同舟云学术

Role of Supramolecule ErpY-Like Lipoprotein of Leptospira in Thrombin-Catalyzed Fibrin Clot Inhibition and Binding to Complement Factors H and I, and Its Diagnostic Potential

Published:2019-12 Issue:12 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Ghosh Karukriti Kaushik¹,Prakash Aman¹,Dhara Anusua¹,Hussain Md Saddam¹,Shrivastav Prateek¹,Kumar Pankaj²,Balamurugan Vinayagamurthy³,Kumar Manish¹

Affiliation:

1. Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, India

2. ICAR Research Complex for Eastern Region–ICAR Parisar, Patna, India

3. Indian Council of Agricultural Research-National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Bengaluru, India

Abstract

Leptospirosis is one of the most widespread zoonoses caused by pathogenic Leptospira spp. In this study, we report that the LIC11966/ErpY-like lipoprotein is a surface-exposed outer membrane protein exclusively present in pathogenic species of Leptospira . The recombinant ErpY (rErpY)-like protein is recognized by the immunoglobulins of confirmed leptospirosis sera of diverse hosts (human, bovine, and canine), suggesting the expression of the native leptospiral surface protein during infection.

Funder

DST | Science and Engineering Research Board

Indian Council of Medical Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00536-19

Reference65 articles.

1. Leptospirosis: a zoonotic disease of global importance

2. Global Morbidity and Mortality of Leptospirosis: A Systematic Review