Ascaris Larval Infection and Lung Invasion Directly Induce Severe Allergic Airway Disease in Mice-Reference-Cited by-同舟云学术

Ascaris Larval Infection and Lung Invasion Directly Induce Severe Allergic Airway Disease in Mice

Published:2018-12 Issue:12 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Weatherhead Jill E.¹²³,Porter Paul²,Coffey Amy⁴,Haydel Dana⁴,Versteeg Leroy¹,Zhan Bin¹³,Gazzinelli Guimarães Ana Clara⁵,Fujiwara Ricardo⁵,Jaramillo Ana M.⁶,Bottazzi Maria Elena¹³⁷⁸,Hotez Peter J.¹³⁷⁸,Corry David B.²⁴⁹¹⁰,Beaumier Coreen M.¹⁷

Affiliation:

1. Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA

2. Department of Medicine, Baylor College of Medicine, Houston, Texas, USA

3. National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, USA

4. Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA

5. Departamento de Parasitologia, Federal University of Minas Gerais, Minas Gerais, Brazil

6. Department of Pulmonary Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

7. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA

8. Texas Children’s Hospital Center for Vaccine Development-Product Development Partnership, Houston, Texas, USA

9. Biology of Inflammation Center, Baylor College of Medicine, Houston, Texas, USA

10. Michael E. DeBakey Center for Translational Research in Inflammatory Diseases, Houston, Texas, USA

Abstract

Ascaris lumbricoides (roundworm) is the most common helminth infection globally and a cause of lifelong morbidity that may include allergic airway disease, an asthma phenotype. We hypothesize that Ascaris larval migration through the lungs leads to persistent airway hyperresponsiveness (AHR) and type 2 inflammatory lung pathology despite resolution of infection that resembles allergic airway disease.

Funder

Michelson Medical Research Foundation

Baylor College of Medicine Pathology and Histology Cancer Center

Veterans Affairs office of research and development

HHS | National Institutes of Health

DH | National Institute for Health Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00533-18

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