True Measles Cases Undetected by Reverse Transcription-PCR (RT-PCR): Effect of Genetic Variability on Assay Sensitivity Needs To Be Regularly Surveyed

Author:

Dina Julia12ORCID,Omnes Jordane12,Vauloup-Fellous Christelle234,Collet Louis3,Hamel Justine1,Antona Denise5,Hübschen Judith M.6,Ben Mamou Myriam7,Vabret Astrid12

Affiliation:

1. Virology Department, Normandy University, UNICAEN, GRAM EA2656, CHU de Caen, Caen, France

2. National Reference Center for Measles Mumps and Rubella, CHU de Caen, Caen, France

3. Centre Hospitalier de Mayotte, Mamoudzou, Mayotte, France

4. University Paris Sud, INSERM U1193, Villejuif, France

5. Direction des maladies infectieuses, Santé Publique France, Saint-Maurice, France

6. Department of Infection and Immunity, Infectious Diseases Research Unit, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg

7. World Health Organization, Regional Office for Europe, Copenhagen, Denmark

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference8 articles.

1. Progress Toward Regional Measles Elimination — Worldwide, 2000–2017

2. The Unfinished Measles Immunization Agenda

3. WHO. 2018. Manual for the laboratory-based surveillance of measles, rubella, and congenital rubella syndrome, 3rd ed. WHO, Geneva, Switzerland.

4. Development of quantitative gene-specific real-time RT-PCR assays for the detection of measles virus in clinical specimens

5. Genetic diversity of wild-type measles viruses and the global measles nucleotide surveillance database (MeaNS);Mulders MN;Wkly Epidemiol Rec,2015

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