Performance of the Cepheid Methicillin-Resistant Staphylococcus aureus/S. aureus Skin and Soft Tissue Infection PCR Assay on Respiratory Samples from Mechanically Ventilated Patients for S. aureus Screening during the Phase 2 Double-Blind SAATELLITE Study-Reference-Cited by-同舟云学术

Performance of the Cepheid Methicillin-Resistant Staphylococcus aureus/S. aureus Skin and Soft Tissue Infection PCR Assay on Respiratory Samples from Mechanically Ventilated Patients for S. aureus Screening during the Phase 2 Double-Blind SAATELLITE Study

Published:2022-07-20 Issue:7 Volume:60 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Ruzin Alexey¹,Barraud Olivier²^ORCID,Yu Li³,François Bruno²,Sánchez-Garcia Miguel⁴,Eggimann Philippe⁵,Dequin Pierre-François⁶,Laterre Pierre-François⁷,Huberlant Vincent⁸,Viña Lucia⁹,Boulain Thierry¹⁰,Bretonniere Cedric¹¹,Pugin Jérôme¹²,Trenado José¹³,Hernandez Padilla Ana Catalina²,Vignaud Julie²,Vandamme Drieke²,Goossens Herman¹⁴,Lammens Christine¹⁴,Ali S. Omar¹,Shoemaker Kathryn¹⁵,Ren Pin¹⁵,Colbert Susan¹⁶,Bellamy Terramika¹,Sellman Bret R.¹,McCarthy Michael¹⁷,Jafri Hasan S.¹,Esser Mark T.¹

Affiliation:

1. Early Vaccines & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA

2. ICU and Inserm CIC-1435 and UMR-1092, Centre Hospitalier Universitaire de Limoges, Limoges, France

3. Statistical Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA

4. Hospital Clinico San Carlos, Madrid, Spain

5. Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

6. Université François Rabelais, Tours, France

7. St. Luc University Hospital, Brussels, Belgium

8. Centre Hospitalier Jolimont-Lobbes, Lobbes, Belgium

9. Hospital Universitario Central de Asturias, Oviedo, Spain

10. Centre Hospitalier Régional d’Orléans, Orléans, France

11. Hôpital Guillaume et René Laennec, Nantes, France

12. Hôpitaux Universitaire de Genève, Geneva, Switzerland

13. Hospital Mutua de Terrassa, Terrassa, Spain

14. Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp, Antwerp, Belgium

15. Late-Stage Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA

16. Development Operations, BioPharmaceuticals R&D, AstraZeneca, Wilmington, Delaware, USA

17. Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA

Abstract

We investigated the performance of the Xpert methicillin-resistant Staphylococcus aureus (MRSA)/ S. aureus skin and soft tissue (SSTI) quantitative PCR (qPCR) assay in SAATELLITE, a multicenter, double-blind, phase 2 study of suvratoxumab, a monoclonal antibody (MAb) targeting S. aureus alpha-toxin, for reducing the incidence of S. aureus pneumonia.

Funder

COMBACTE Consortium

Innovative Medicines Initiative Joint Undertaking

AstraZeneca

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/jcm.00347-22

Reference24 articles.

1. Guidelines for the Management of Adults with Hospital-acquired, Ventilator-associated, and Healthcare-associated Pneumonia