Occult Hepatitis C Virus Infection Revisited with Ultrasensitive Real-Time PCR Assay-Reference-Cited by-同舟云学术

Occult Hepatitis C Virus Infection Revisited with Ultrasensitive Real-Time PCR Assay

Published:2008-06 Issue:6 Volume:46 Page:2106-2108
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Halfon Philippe¹,Bourlière Marc²,Ouzan Denis³,Sène Damien⁴,Saadoun David⁴,Khiri Hacène¹,Pénaranda Guillaume⁵,Martineau Agnes¹,Oulès Valérie²,Cacoub Patrice⁴

Affiliation:

1. Laboratoire Alphabio, Hôpital Ambroise Paré, Marseille, France

2. Département d'Hépato-Gastroentérologie, Hôpital Saint-Joseph, Marseille, France

3. Département d'Hépato-Gastroentérologie, Institut Arnault Tzanck, Saint-Laurent du Var, France

4. Université Pierre et Marie Curie-Paris 6, CNRS, UMR 7087-AP-HP, Hôpital Pitié-Salpêtrière, Service de Médecine Interne, Paris, France

5. Département Biostatistiques, CDL Pharma, Marseille, France

Abstract

ABSTRACT Occult hepatitis C infection is regarded as a new entity that should be considered when diagnosing patients with a liver disease of unknown origin. Using an ultrasensitive real-time PCR assay, we demonstrated that occult hepatitis C virus (HCV) infection cannot be found in peripheral blood mononuclear cells of patients with cryptogenic liver diseases, HCV-associated systemic vasculitis, or connective tissue diseases. The significance of such occult infection must be elucidated.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00345-08

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