Occult Hepatitis C Virus Infection Revisited with Ultrasensitive Real-Time PCR Assay

Author:

Halfon Philippe1,Bourlière Marc2,Ouzan Denis3,Sène Damien4,Saadoun David4,Khiri Hacène1,Pénaranda Guillaume5,Martineau Agnes1,Oulès Valérie2,Cacoub Patrice4

Affiliation:

1. Laboratoire Alphabio, Hôpital Ambroise Paré, Marseille, France

2. Département d'Hépato-Gastroentérologie, Hôpital Saint-Joseph, Marseille, France

3. Département d'Hépato-Gastroentérologie, Institut Arnault Tzanck, Saint-Laurent du Var, France

4. Université Pierre et Marie Curie-Paris 6, CNRS, UMR 7087-AP-HP, Hôpital Pitié-Salpêtrière, Service de Médecine Interne, Paris, France

5. Département Biostatistiques, CDL Pharma, Marseille, France

Abstract

ABSTRACT Occult hepatitis C infection is regarded as a new entity that should be considered when diagnosing patients with a liver disease of unknown origin. Using an ultrasensitive real-time PCR assay, we demonstrated that occult hepatitis C virus (HCV) infection cannot be found in peripheral blood mononuclear cells of patients with cryptogenic liver diseases, HCV-associated systemic vasculitis, or connective tissue diseases. The significance of such occult infection must be elucidated.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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