The C-Type Lectin Receptor Dectin-2 Is a Receptor for Aspergillus fumigatus Galactomannan

Author:

Reedy Jennifer L.12,Crossen Arianne J.1,Negoro Paige E.1,Harding Hannah Brown1,Ward Rebecca A.1,Vargas-Blanco Diego A.1,Timmer Kyle D.1,Reardon Christopher M.1,Basham Kyle J.1,Mansour Michael K.12,Wüthrich Marcel3,Fontaine Thierry4,Latgé Jean-Paul5,Vyas Jatin M.12ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA

2. Harvard Medical School, Department of Medicine, Boston, Massachusetts, USA

3. Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, Wisconsin, USA

4. Institut Pasteur, Université de Paris, INRAE, USC2019, Unité Biologie et Pathogénicité Fongiques, Paris, France

5. Institute of Molecular Biology and Biotechnology (IMBBFORTH), University of Crete, Heraklion, Greece

Abstract

Aspergillus fumigatus is a fungal pathogen that causes serious and often fatal disease in humans. The surface of Aspergillus is composed of complex sugar molecules.

Funder

KL2/Catalyst Medical Research Investigator Training Award from Harvard Catalyst

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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