Affiliation:
1. Food Safety Laboratory, College of Food Science and Engineering, Ocean University of China, Qingdao, China
Abstract
Phage resistance is a major limitation of phage therapy, and understanding the mechanisms by which bacteria block phage infection is critical for the successful application of phage therapy. In the present study, we found that
Pseudomonas aeruginosa
PAO1 uses
las
QS to promote phage infection by upregulating the expression of
galU
, which is necessary for the synthesis of phage receptor lipopolysaccharides.
Funder
MOST | National Key Research and Development Program of China
China Agricultural Research System
Publisher
American Society for Microbiology
Cited by
21 articles.
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