Genomic Drivers of Multidrug-Resistant Shigella Affecting Vulnerable Patient Populations in the United States and Abroad

Author:

Worley Jay Noboru12,Javkar Kiran34ORCID,Hoffmann Maria5,Hysell Kristen67,Garcia-Williams Amanda8,Tagg Kaitlin89,Kanjilal Sanjat10ORCID,Strain Errol11,Pop Mihai3,Allard Marc5,Francois Watkins Louise8,Bry Lynn110ORCID

Affiliation:

1. Massachusetts Host-Microbiome Center, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

2. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA

3. Center for Bioinformatics and Computational Biology, University of Maryland, College Park, College Park, Maryland, USA

4. Joint Institute for Food Safety and Applied Nutrition, University of Maryland, College Park, College Park, Maryland, USA

5. Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Department of Health and Human Services, College Park, Maryland, USA

6. Division of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA

7. Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA

8. Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

9. Weems Design Studio, Inc., Suwanee, Georgia, USA

10. Clinical Microbiology Laboratory, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

11. Center for Veterinary Medicine, United States Food and Drug Administration, Department of Health and Human Services, Laurel, Maryland, USA

Abstract

Multidrug-resistant Shigella isolates with resistance to macrolides are an emerging public health threat. We define a plasmid/pathogen complex behind infections seen in the United States and globally in vulnerable patient populations and identify multiple outbreaks in the United States and evidence of intercontinental transmission.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

HHS | National Institutes of Health

HHS | NIH | U.S. National Library of Medicine

Massachusetts Life Sciences Center

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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