Candida albicans Enhances the Progression of Oral Squamous Cell Carcinoma In Vitro and In Vivo

Author:

Vadovics Máté12,Ho Jemima3,Igaz Nóra24,Alföldi Róbert5,Rakk Dávid12,Veres Éva12,Szücs Balázs1,Horváth Márton1,Tóth Renáta1,Szücs Attila1,Csibi Andrea1,Horváth Péter6,Tiszlavicz László7,Vágvölgyi Csaba1,Nosanchuk Joshua D.89,Szekeres András1,Kiricsi Mónika4,Henley-Smith Rhonda10,Moyes David L.3,Thavaraj Selvam11,Brown Rhys3,Puskás László G.5,Naglik Julian R.3,Gácser Attila1213ORCID

Affiliation:

1. Department of Microbiology, University of Szeged, Szeged, Hungary

2. Doctoral School of Biology, University of Szeged, Szeged, Hungary

3. Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, London, United Kingdom

4. Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, Hungary

5. AstridBio Technologies Ltd., Szeged, Hungary

6. Synthetic and System Biology Unit, Biological Research Centre (BRC), Szeged, Hungary

7. Department of Pathology, University of Szeged, Szeged, Hungary

8. Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA

9. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA

10. King’s Health Partners, Head and Neck Cancer Biobank, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom

11. Centre for Oral, Clinical and Translational Science, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, London, United Kingdom

12. HCEMM-USZ Fungal Pathogens Research Group, Department of Microbiology, University of Szeged, Szeged, Hungary

13. MTA-SZTE Lendület Mycobiome Research Group, University of Szeged, Szeged, Hungary

Abstract

Oral squamous cell carcinoma (OSCC) is a serious health issue worldwide that accounts for 2% to 4% of all cancer cases. Previous studies have revealed a higher yeast carriage and diversity in oral cancer patients than in healthy individuals.

Funder

Magyarország Kormánya

Nemzeti Kutatási, Fejlesztési és Innovaciós Alap

Magyar Tudományos Akadémia

European Commission

Wellcome Trust

National Research, Development and Innovation Office

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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