Determinants and Mechanisms of the Low Fusogenicity and High Dependence on Endosomal Entry of Omicron Subvariants-Reference-Cited by-同舟云学术

Determinants and Mechanisms of the Low Fusogenicity and High Dependence on Endosomal Entry of Omicron Subvariants

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Qu Panke¹²,Evans John P.¹²³,Kurhade Chaitanya⁴,Zeng Cong¹²,Zheng Yi-Min¹²,Xu Kai¹²,Shi Pei-Yong⁴,Xie Xuping⁴^ORCID,Liu Shan-Lu¹²⁵⁶^ORCID

Affiliation:

1. Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, USA

2. Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA

3. Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, Ohio, USA

4. Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA

5. Viruses and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, Ohio, USA

6. Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA

Abstract

Omicron has been shown to predominantly use the endosomal entry pathway, resulting in reduced lung tropism and reduced disease severity; however, the underlying mechanism is not fully understood. In addition, whether the most recent Omicron subvariants, including BA.5 and BA.2.75, use the same pathway as their ancestor for entry is currently not known.

Funder

An anonymous private donor to OSU

Glenn Barber Fellowship from the Ohio State University

Comprehensive Cancer Center at the Ohio State University

Center for Clinical & Translational Science at the Ohio State University

The Kleberg Foundation

Summerfield Robert Foundation

Edith and Robert Zinn

Amon G. Carter Foundation

HHS | NIH | National Cancer Institute

HHS | National Institutes of Health

John S. Dunn Foundation