Humans Are Selectively Exposed to Pneumocystis jirovecii-Reference-Cited by-同舟云学术

Humans Are Selectively Exposed to Pneumocystis jirovecii

Published:2020-04-28 Issue:2 Volume:11 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Cissé Ousmane H.¹^ORCID,Ma Liang¹^ORCID,Jiang Chao²,Snyder Michael²^ORCID,Kovacs Joseph A.¹^ORCID

Affiliation:

1. Critical Care Medicine Department, NIH Clinical Center, Bethesda, Maryland, USA

2. Department of Genetics, Stanford University School of Medicine, Stanford, California, USA

Abstract

Environmental exposure has a significant impact on human health. While some airborne fungi can cause life-threatening infections, the impact of environment on fungal spore dispersal and transmission is poorly understood. The democratization of shotgun metagenomics allows us to explore important questions about fungal propagation. We focus on Pneumocystis , a genus of host-specific fungi that infect mammals via airborne particles. In humans, Pneumocystis jirovecii causes lethal infections in immunocompromised patients if untreated, although its environmental reservoir and transmission route remain unclear.

Funder

HHS | National Institutes of Health

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | NIH Clinical Center

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03138-19

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